Effect of varying doses of intraveneous paracetamol on the electrical activity of the brain in penicillin induced status epilepticus in rats
Yazarlar (5)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Turgut Özal Üniversitesi, Türkiye
Yıldırım Beyazıt Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynep ACUNGİL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | Journal of the Turkish Epilepsi Society |
| Dergi ISSN | 1300-7157 |
| Dergi Tarandığı Indeksler | Türkiye Atıf Dizini, Türk Medline, DOAJ, GALE, CINAHL |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2015 |
| Cilt No | 21 |
| Sayı | 1 |
| Sayfalar | 13 / 19 |
| DOI Numarası | 10.5505/epilepsi.2015.30085 |
| Makale Linki | http://www.epilepsidergisi.com/jvi.asp?pdir=epilepsi&plng=tur&un=JTES-30085&look4= |
| Özet |
| Objectives Paracetamol is a widely used analgesic and antipyretic agent. It has been reported that N-arachidonoyl-phenolamine, the active metabolite of paracetamol, reduces epilepsy by activating the endocannabinoid system in some models of experimental epilepsy. Diazepam is a benzodiazepine well known to have anticonvulsant effects. The aim of the present study was to investigate the effects of different doses of paracetamol on penicillin-induced epileptiform activity (PIEA) in rats. Methods Rats anesthetized with urethane (1.25 g/kg, intraperitoneal) were placed in a stereotaxic frame. Body temperatures were maintained at 37 C by a heating blanket. An epileptic focus was produced by 500 IU Penicillin G (PGP) injection into the soma-motor cortex using a hole drilled into the cranium. Paracetamol (100, 150 and 300 mg/kg, respectively) and diazepam (5 mg/kg) were administered thirty minutes after PGP injection, and their effects on the epileptiform activity were examined comparatively. Electrocorticographic activity was monitored for two hours. Results Intracortical injection of PGP (500 units) induced epileptiform activity in all groups of rats. Diazepam caused a statistical significant decrease in the epileptiform activity in the 40th minute after PGP injection. Paracetamol (100 mg/kg) application did not influence the PIEA (p> 0.05). However, 150 and 300 mg/kg IV paracetamol had a statistically significant effect on the antiepileptic activity (p< 0.001). Conclusion The results of the present study indicated that 150 and 300 mg/kg doses of paracetamol had an effect on PIEA. Further studies are needed to understand the reasons for this effect. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 5 |