The Impact of PER3 VNTR Polymorphism on the Development of Schizophrenia in a Turkish Population
Yazarlar (5)
Doç. Dr. Filiz ÖZSOY Türkiye
Prof. Dr. Serbülent Yiğit Türkiye
Prof. Dr. Ayşe Feyda Nursal Türkiye
Müberra Kulu
Nevin Balcı Karakuş
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | CYTOLOGY AND GENETICS (Q3) | ||
| Dergi ISSN | 0095-4527 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2021 |
| Cilt / Sayı / Sayfa | 55 / 2 / 188–193 | DOI | 10.3103/S0095452721020109 |
| Makale Linki | 10.3103/S0095452721020109 | ||
| UAK Araştırma Alanları |
Ruh Sağlığı ve Hastalıkları
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| Özet |
| Introduction Up to 80% of patients who suffer from schizophrenia have sleep impairments, which affect physical and mental health, as well as quality of life. Several tandem repeat polymorphisms (VNTRs) in the Period 3 (Per3) gene have been associated with heritable sleep and circadian variables. The purpose of this study is to investigate the relationship between the VNTR variant of the PER3 gene and genetic predisposition of schizophrenia in a Turkish population. Method Blood samples were taken from 100 patients with schizophrenia, and from 100 normal controls who are age and sex-matched. PER3 genotyping was performed on DNA by polymerase chain reaction (PCR) using specific primers. Results For the PER3 VNTR polymorphism, we found no significant differences in the genotype distribution and allele frequency, between the schizophrenia and control groups. No association was noted between … |
| Anahtar Kelimeler |
| Schizophrenia | Period 3 | gene | polymorphism | PCR | VNTR |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Google Scholar | 4 |