The protective effect of single dose tadalafil in contrast induced nephropathy An experimental study
Yazarlar (9)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Akdeniz Üniversitesi, Türkiye
İzmir Katip Çelebi Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Metin KARAYAKALI
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Balıkesir Üniversitesi, Türkiye
Prof. Dr. Reşit Doğan KÖSEOĞLU
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Karabük Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | The Anatolian Journal of Cardiology |
| Dergi ISSN | 2149-2263 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2015 |
| Cilt No | 15 |
| Sayı | 4 |
| Sayfalar | 306 / 310 |
| DOI Numarası | 10.5152/akd.2014.5380 |
| Makale Linki | http://anatoljcardiol.com/jvi.aspx?un=AJC-38632 |
| Özet |
| Objective: Contrast-induced nephropathy (CIN) is one of the most common causes of acute renal failure in hospitalized patients. The directtoxic effect of contrast media; ischemic damage caused by reactive oxygen species; increased perivascular hydrostatic pressure; high viscos-ity and changes in the activity of vasoactive substances play important roles in the pathogenesis. Tadalafil inhibits the phosphodiesteraseenzyme which destroys nitric oxide. Nitric oxide causes renal vasodilatation, increases renal medullar blood flow and mediates the removal offree oxygen radicals. Drugs that increase levels of nitric oxide are expected to reduce the development of contrast nephropathy due to contrastmedia. We aimed to test the hypothesis that tadalafil reduces the development of contrast nephropathy due to contrast toxicity.Methods: A total of 24 female Wistar albino rats, three groups of eight, were included in the study. After 48 hours of dehydration, contrast media(meglumine diatrozoate, 6 mL/kg) was administered to the first group, and contrast media with tadalafil (10 mg/kg) was administered to thesecond group. The third group served as the control group. Blood and tissue samples were taken 48 hours after this procedure.Results: Serum cystatin C, serum creatinine and blood urea nitrogen (BUN) values were significantly lower in the contrast with tadalafil groupcompared to the group given only contrast. Serum and tissue malondialdehyde (MDA) levels were significantly lower in the contrast withtadalafil group than in the contrast only group.Conclusion: These results demonstrate the protective effect of tadalafil in the prevention of CIN in rats. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| TRDizin | 2 |