Preparation and cytotoxicity evaluation of some amino acid methyl ester schiff bases
Yazarlar (3)
Dr. Öğr. Üyesi Nilay Akkuş Taş Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Ayşegül ŞENOCAK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ali Aydın Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of the Turkish Chemical Society Section A Chemistry | ||
| Dergi ISSN | 2149-0120 Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2018 |
| Cilt / Sayı / Sayfa | 5 / 2 / 585–606 | DOI | 10.18596/jotcsa.373904 |
| Makale Linki | https://dergipark.org.tr/en/download/article-file/453905 | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| In this study, we prepared nine Schiff bases by condensation of amino acid methyl esters (isoleucine, phenylalanine, and methionine) with salicylaldehyde derivatives (2,4-dihydroxybenzaldehyde, 2-hydroxy-3-methoxybenzaldehyde, and 5-bromo-2-hydroxybenzaldehyde) and characterized by various spectroscopic methods (FT-IR, UV-Vis, and NMR techniques). FT-IR and UV-Vis spectra exhibited characteristic peaks for all imine compounds. NMR spectra pointed out the imine bond which is the indicator of the formation of Schiff bases. Besides, antiproliferative and cytotoxic features of the Schiff bases were examined by using MTT cell proliferation and LDH cytotoxicity assays, respectively. Amongst the synthesized Schiff bases, compound 3d exhibited a very strong antiproliferative effect against all cells except A549. The experimental studies revealed that the Schiff bases synthesized in this study, especially 3d, have an important potential to enter drug developmental studies. |
| Anahtar Kelimeler |
| Amino acid Schiff bases | Antiproliferative activity | Cytotoxicity | NMR spectra | Salicylaldehyde |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 9 |
| Google Scholar | 10 |