Favourable effects of whey protein upon acetic acid-induced ulcerative colitis in rat model
Yazarlar (7)
Türkiye
Prof. Dr. Abdurahman ŞAHİN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Türkiye
Türkiye
Türkiye
Fırat Üniversitesi, Türkiye
Fırat Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | ARCHIVES OF MEDICAL SCIENCE |
| Dergi ISSN | 1734-1922 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2022 |
| Cilt No | 18 |
| Sayı | 6 |
| Sayfalar | 1617 / 1625 |
| DOI Numarası | 10.5114/aoms/105839 |
| Makale Linki | http://dx.doi.org/10.5114/aoms/105839 |
| Özet |
| In the present study, we aimed to examine the effects of the administration of whey protein through rectal enema to rats with acetic acid-induced ulcerative colitis on the pathways of nuclear-related factor-2 (Nrf-2), haem oxygenase-1 (HO-1), nuclear factor κB (NF-κB), active protein kinase-1 (AP-1), tumour necrotising factor-α (TNF-α), and cyclooxygenase-2 (COX-2), IL-6, IL-10. Twenty-eight rats were employed for the trial. Ulcerative colitis was induced through the use of acetic acid. The therapeutic doses of whey protein were administered rectally. Ulcerative colitis was subjected to histopathological examination and protein levels in colon tissue were measured with the Western blot method. The significant increases observed in the levels of AP-1, COX-2, IL-6, IL-10, NF-κB, and TNF-α as markers of inflammation following the development of ulcerative colitis showed remarkable decreases along with the administration of whey protein ( < 0.05). On the other hand, we identified a decrease in the Nrf2-ARE signal pathway and HO-1 protein having protective roles in the colon inflammatory response along with the development of ulcerative colitis and activation of the Nrf2-HO-1 pathway by the whey protein. Whey protein modulates Nrf2/HO-1 and NF-kB pathways, thereby creating a therapeutic effect against colonic inflammation induced by acetic acid (AA) due to its anti-inflammatory effects. |
| Anahtar Kelimeler |
| whey protein | Nrf2 | HO-1 | NF-KB pathway | acetic acid-induced ulcerative colitis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 7 |
| Google Scholar | 8 |