Possible protective effect of remifentanil against testicular ischemia-reperfusion injury
Yazarlar (11)
Dr. Öğr. Üyesi Vildan KÖLÜKÇÜ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mardin Artuklu Üniversitesi, Türkiye
Doç. Dr. Muzaffer KATAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Mehtap GÜRLER BALTA
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Hakan TAPAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Tuğba KARAMAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serkan KARAMAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Fatih FIRAT
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Kenan YALÇIN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Öğr. Gör. Yunus Emre KUYUCU
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
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| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Türk Biyokimya Dergisi |
| Dergi ISSN | 1303-829X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2024 |
| Cilt No | 49 |
| Sayı | 6 |
| Sayfalar | 801 / 809 |
| DOI Numarası | 10.1515/tjb-2024-0111 |
| Makale Linki | https://www.degruyter.com/journal/key/tjb/html |
| Özet |
| Objectives: This study aims to evaluate the protective effi- cacy of remifentanil against testicular ischemia-reperfusion injury. Methods: The study included 24 male rats. The rats were randomized into three groups: Group 1 was the control group. Group 2 was subjected to a testicular torsion/ detorsion model. Group 3 underwent similar procedures and additionally received remifentanil (0.6 μg/kg/min) intrave- nously for the first 20 min of reperfusion. Blood samples were taken for biochemical analyses, and orchiectomy was performed for histopathologic examination. Results: Biochemical analysis of blood samples showed a significant increase in antioxidant enzyme activity, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in Group 3 compared to Group 2 (p:0.004 and p:0.002, respectively). There was a dramatic decrease in the levels of proinflammatory cytokines, including interleukin-1 beta (IL-1 Beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in Group 3 compared to Group 2 (p:0.001, p:0.046, and p:0.004, respectively). Similarly, malondialdehyde (MDA) levels decreased in Group 3 compared to Group 2 (p:0.004). Histopathologic examination of Group 3 rats showed positive changes in inflammation, hemorrhage, edema, and conges- tion levels compared to Group 2 (p<0.001). Similarly, there was a positive effect on the Johnsen and Cosentino score in Group 3 compared to Group 2 (p:0.001 and p<0.001, respectively). Conclusions: In our study, it has been documented that remifentanil protects against testicular ischemia-reperfusion injury. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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