The Relationship Between Hepatic Activity Index and Serum Tumor Necrosis Factor Alpha Levels in Patients with Chronic Active Hepatitis B and Chronic Active Hepatitis C
Yazarlar (9)
İnönü Üniversitesi, Türkiye
İnönü Üniversitesi, Türkiye
İnönü Üniversitesi, Türkiye
Prof. Dr. Abdurahman ŞAHİN
Fırat Üniversitesi, Türkiye
Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
İnönü Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale |
| Dergi Adı | Medicine Science International Medical Journal |
| Dergi ISSN | 2147-0634 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | Türkçe |
| Basım Tarihi | 04-2015 |
| Cilt No | 4 |
| Sayı | 4 |
| Sayfalar | 2772 / 2781 |
| DOI Numarası | 10.5455/medscience.2015.04.8283 |
| Makale Linki | http://www.scopemed.org/?mno=182688 |
| Özet |
| In the present study, we investigated the relationship between serum TNF-α levels and hepatic activity in liver biopsies of chronic hepatitis B and C patients.The study was performed on 30 chronic hepatitis B patients, 25 chronic hepatitis C patients and 25 healthy controls. Serum samples of patients who underwent biopsy and healthy controls were collected. Control group was seronegative for hepatitis and had normal liver function tests. TNF- α levels measured by ELISA. Knodell’s hepatic activity index was used in evaluation of liver biopsies. Serum TNF-α levels were determined higher in chronic hepatitis B and C patients than control group. HAI and TNF- α compared in chronic hepatitis B and C patients. Although we detected a relationship between HAI and TNF-α levels in chronic hepatitis B patients, no true correlation was shown in chronic hepatitis C patients. Cytokines have an important role in progression of chronic hepatitis B and C infections. There is a relationship between hepatic activity index and TNF-α level in chronic hepatitis B infection.But There is not relationship between hepatic activity index and chronic hepatitis C infection.only in two patients and both of them where in the middle of their reproductive age while as symptomatic ovarian cysts was a more common finding in unmarried females in 21-28 years of age group. This study concluded that laparoscopy has a diagnostic as well as a therapeutic implication in management of NSAP. Keywords: Hepatic activity index, serum tumor necrosis factor alpha, chronic active hepatitis-b, chronic active hepatitis-c |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 3 |