Evaluation of Ischemia-Modified Albumin in Patients with Inflammatory Bowel Disease
Yazarlar (8)
Kırklareli Üniversitesi, Türkiye
Prof. Dr. Abdurahman ŞAHİN
Fırat Üniversitesi, Türkiye
Training And Research Hospital, Türkiye
Umranive Training Ami Research Hospital, Türkiye
Medeniyet University Coztepe Education And Research Hospital, Türkiye
Dr. Abdurahmanyurtarslan Oncology Education And Research Hospital, Türkiye
Umranive Training Ami Research Hospital, Türkiye
Umranive Training Ami Research Hospital, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Clinical Laboratory |
| Dergi ISSN | 1433-6510 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2017 |
| Cilt No | 63 |
| Sayı | 2 |
| Sayfalar | 341 / 347 |
| DOI Numarası | 10.7754/Clin.Lab.2016.160623 |
| Özet |
| Background: Inflammatory bowel disease (IBD) is considered a chronic gastrointestinal inflammatory disease with unknown etiology. Oxidative stress has been demonstrated to play a critical role in the pathophysiology of IBD. We aimed to investigate the effect of the ischemia-modified albumin (IMA) and CRF levels on the pathophysiology and activities of IBD and its subgroups. Methods: The study included 39 patients with Crohn's disease (CD) and 41 patients with ulcerative colitis (UC). Thirty-three healthy volunteers participated in the study as the control group. The IMA concentrations were determined by colorimetric method. Results: IMA levels were significantly higher in IBD than in the controls (p = 0.02). In the subgroups of IBD, IMA levels were significantly lower in the control group and CD group than in UC (p < 0.001 and p < 0.001, respectively) while IMA levels were significant higher in the UC when compared with the CD group (p < 0.001). C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels were significantly higher in the CD group compared to the control group (p < 0.01 and p < 0.02, respectively). Conclusions: Higher IMA level, which is a marker of oxidative stress in diseases with inflammation, indicates that inflammation and oxidative stress are related in the pathogenesis of IBD. |
| Anahtar Kelimeler |
| Crohn's disease | CRP | Ischemia-modified albumin | Oxidative stress | Ulcerative colitis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 18 |
| SCOPUS | 20 |
| Google Scholar | 32 |