Potentiometric PVC Membrane Sensor for the Determination of Anti-Epileptic Drug Levetiracetam in Pharmaceutical Formulations
Yazarlar (2)
Doç. Dr. Oğuz ÖZBEK Zonguldak Bülent Ecevit Üniversitesi, Türkiye
Prof. Dr. Ömer IŞILDAK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2022 |
| Kabul Tarihi | 04-01-2022 | Yayınlanma Tarihi | 18-01-2022 |
| Cilt / Sayı / Sayfa | 7 / 3 / – | DOI | 10.1002/slct.202103988 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202103988 | ||
| Özet |
| A poly(vinyl chloride) (PVC) membrane potentiometric sensor was developed for the determination of anti‐epileptic drug levetiracetam. For this purpose, levetiracetam‐tetraphenylborate (LEV‐TPB) ion‐pair was synthesized and the synthesized ion‐pair was used as ionophore in PVC membrane structures. The membrane composed of 3.0 % (w/w) LEV‐TPB ion‐pair, 32.0 % (w/w) PVC, and 65.0 % (w/w) o‐nitrophenyloctylether (o‐NPOE) was determined as the membrane with the best potentiometric properties. The developed sensor exhibited a linear response in the concentration range from 1.0×10−5 to 1.0×10−1 mol L−1 and had a detection limit of 6.31×10−6 mol L−1. For this sensor, pH working range and response time were determined as 6.0–8.0 and ≈25 s, respectively. The sensor displayed a good selectivity for levetiracetam in the presence of a number of common ionic species and some anti … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 31 |
| Scopus | 5 |