A NOVEL SENSITIVE AND SELECTIVE POTENTIOMETRIC SENSORFOR RISPERIDONE DETECTION
Yazarlar (2)
Prof. Dr. Ömer IŞILDAK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ayşenur Birinci
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Farmacia (Q4) | ||
| Dergi ISSN | 0014-8237 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 22-12-2018 |
| Cilt / Sayı / Sayfa | 66 / 6 / 977–983 | DOI | 10.31925/FARMACIA.2018.6.8 |
| Makale Linki | https://farmaciajournal.com/wp-content/uploads/2018-06-art-08-Isildak_Birinci_977-983.pdf | ||
| UAK Araştırma Alanları |
Analitik Kimya
|
||
| Özet |
| An antipsychotic drug containing risperidone can be analysed by liquid chromatographic techniques (LC) using UV-visible and fluorescence detectors. However, all developed methods based on LC are expensive, time consuming due to pre-and post-column reaction, and also not very sensitive. The preparation of micro-sized composite risperidone-sensitive sensors and their suitability as detector in a flow-injection analysis system is described. A risperidone-sensitive sensor membrane was prepared by coating a composite cocktail on the surface of the contact transducer in solid state. The composition ratio percentage for the best performance was obtained with 2.5%(w/w) active ingredient (ionophore), 67%(w/w) plasticizer, 30%(w/w) PVC, and 0.5% sodium tetraphenyl borate. The potentiometric performances of risperidone-selective sensor (selectivity constant, liner domain, detection limit, response time, pH working domain, repeatability, lifetime, and time dependent potential decay) were determined using computer controlled measurement systems in static conditions. |
| Anahtar Kelimeler |
| Brome phenol blue | Phenol red | Potentiometric sensor | PVC membrane | Risperidone |
| Atıf Sayıları | |
| Scopus | 3 |
| Google Scholar | 3 |