Bis(2-furanylmethyl)monospiro(N/N)cyclotriphosphazenes: synthesis, structural characterization, antiproliferative, and antimigratory activity studies
Yazarlar (7)
Prof. Dr. Hüseyin AKBAŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Ayşegül ŞENOCAK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Zeynel Kılıç Ankara Üniversitesi, Türkiye
Doç. Dr. Seçil ERDEN TAYHAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Sema BİLGİN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Aslı Yıldırım Kocaman Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tuncer Hökelek Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Phosphorus Sulfur and Silicon and the Related Elements (Q3) | ||
| Dergi ISSN | 1042-6507 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2023 |
| Cilt / Sayı / Sayfa | 198 / 12 / 1040–1049 | DOI | 10.1080/10426507.2023.2242995 |
| Makale Linki | https://figshare.com/articles/journal_contribution/Bis_2-furanylmethyl_monospiro_N_N_cyclotriphosphazenes_synthesis_structural_characterization_antiproliferative_and_antimigratory_activity_studies/23922030 | ||
| Özet |
| In this study, the condensation reaction of hexachlorocyclotriphosphazene, N3P3Cl6 (HCCP) with N1,N3-bis(furan-2-ylmethyl)-1,3-diamino-propane (1) yielded tetrachlorobis(2-furanyl-methyl)monospiro(N/N)cyclotriphosphazene (2). Fully substituted tetraaminobis(2-furanylmethyl)-spiro(N/N)cyclotriphosphazenes (2a and 2b) were obtained by Cl replacement reactions with excess pyrrolidine and piperidine, respectively, using dry THF under reflux of 2. The structures of the phosphazenes were confirmed by data obtained by elemental analysis, FT-IR, ESI-MS, 1H, 13C, and 31P NMR. Moreover, the molecular structure of 2b was elucidated by X-ray crystallography. The antiproliferative effects of phosphazenes (2, 2a, and 2b) on prostate (PC-3) and colon cancer (HT-29) cell lines were determined by cell viability analysis using MTT assay. Antimigratory effects were also investigated by scratch analysis. In addition … |
| Anahtar Kelimeler |
| antimigratory acitivity | antiproliferative activity | Bis(2-furanylmethyl)spirocyclotriphosphazenes | colon cancer | prostate cancer | spectroscopy |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 9 |
| Scopus | 7 |