Changing Trends in the Etiology of Cirrhosis in Türkiye: A Multicenter Nationwide Study
Yazarlar (32)
Türkiye
İstanbul Arel Üniversitesi, Türkiye
T.C. Sağlık Bakanlığı, Türkiye
Türkiye
Ankara Üniversitesi, Türkiye
Hatay Mustafa Kemal Üniversitesi, Türkiye
Türkiye
Sanko Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
Türkiye
Dokuz Eylül Üniversitesi, Türkiye
Türkiye
Mersin Üniversitesi, Türkiye
Dicle Üniversitesi, Türkiye
Türkiye
Kto Karatay Üniversitesi, Türkiye
Prof. Dr. Ayşe KEFELİ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Karadeniz Teknik Üniversitesi, Türkiye
Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Koç Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
İstinye Üniversitesi, Türkiye
Koç Üniversitesi, Türkiye
T.C. Sağlık Bakanlığı, Türkiye
Türkiye
Türkiye
Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Turkish Journal of Gastroenterology |
| Dergi ISSN | 1300-4948 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2024 |
| Cilt No | 35 |
| Sayı | 10 |
| Sayfalar | 772 / 777 |
| DOI Numarası | 10.5152/tjg.2024.23572 |
| Makale Linki | https://doi.org/10.5152/tjg.2024.23572 |
| Özet |
| Background/Aims: The aim of our study was to investigate the underlying causes behind the etiology of cirrhosis in Türkiye. Materials and Methods: The study was comprised of patients with cirrhosis located in the gastroenterology clinics of 28 centers in Türkiye between January 2000 and June 2021. Results: The study group consisted of 4953 cirrhotic patients (median age: 62.2 years, male / female: 58% / 42%). Among the patients, 39% of the patients were compensated, and 61% were decompensated. Furthermore, 47.5% had Child-Pugh class A, 38% had Child- Pugh class B, and 14.5% had Child-Pugh class C. The most frequent complaints were abdominal bloating (28%). Ascites (54.2%) was the most common manifestation of decompensation. The median Child-Pugh and MELD-Na scores were 7.0 and 10.0, respectively. The most common cause of cirrhosis was chronic viral hepatitis (43%), followed by cryptogenic cirrhosis (CC) (19%), metabolic dysfunc- tion-associated steatotic liver disease (MASLD)-related cirrhosis (13%), and alcohol-related cirrhosis (11%). Among the 950 patients with CC, 416 had metabolic abnormalities. If these 416 CC patients with metabolic abnormalities were categorized as having MASLD- related cirrhosis, the proportion of MASLD-related cirrhosis increased to 21%. Thirteen percent of the patients were diagnosed with HCC, while 4% had extrahepatic malignancy. Female breast cancer (18%) and colorectal cancer (18%) were the most frequent extra- hepatic malignancies. Conclusion: Viral hepatitis remains the main cause of cirrhosis in Türkiye. However, its prevalence seems to be declining, whereas the prevalence of steatotic liver disease-related cirrhosis is increasing |
| Anahtar Kelimeler |
| Cirrhosis | etiology | viral hepatitis | metabolic dysfunction-associated steatotic liver disease | hepatocellular carcinoma |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| TRDizin | 4 |