Determination of Oxidative Stress and Copeptin Levels of COVID-19 According to the Clinical Course.
Yazarlar (4)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Figen GÜZELGÜL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mersin Üniversitesi, Türkiye
Mersin Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Microbial Pathogenesis |
| Dergi ISSN | 0882-4010 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2025 |
| Cilt No | 199 |
| Sayı | 1 |
| DOI Numarası | 10.1016/j.micpath.2024.107263 |
| Makale Linki | https://doi.org/10.1016/j.micpath.2024.107263 |
| Özet |
| COVID-19, caused by the novel coronavirus SARS-CoV-2, is characterized by hyperinflammation, which can trigger oxidative stress. At the same time, COVID-19 is accompanied by both psychological and physical stress. Copeptin, a novel stress marker, has been shown to predict disease outcomes in stress-induced diseases. In this study, we aimed to explore the potential of copeptin, with inflammatory and oxidative stress markers, in distinguishing between different clinical courses of COVID-19. This case-control study included 75 participants: 25 COVID-19 patients hospitalized in the intensive care unit (ICU), 25 non-ICU COVID-19 patients, and 25 healthy individuals. 64 % of the ICU patients received corticosteroid treatment for 4-10 days before sampling. Serum concentrations of the study parameters were assessed by enzyme-linked immunosorbent assay (ELISA) and compared between the study groups. Serum IL-6 levels (p < 0.001) were significantly higher in ICU patients compared to non-ICU patients and the control group. Serum MDA (p < 0.001) and 4-HNE (p = 0.027) concentrations were significantly lower in the ICU group in comparison with the other groups. Copeptin was not statistically significant. MDA (p = 0.040) and 4-HNE (p = 0.017) levels were significantly lower in the treated ICU group than the untreated one. Serum IL-6 levels were noticeably associated with COVID-19 severity. Corticosteroid therapy administration seemed to influence MDA and 4-HNE levels in the treated group, with no obvious influence on IL-6 and copeptin in the same cohort. This data suggests that in SARS-CoV-2 infection, corticosteroids may act through a rapid non-genomic mechanism. |
| Anahtar Kelimeler |
| Oxidative stress | Inflammation | Copeptin | COVID-19 | Corticosteroids |
Science Direct
Determination of Oxidative Stress and Copeptin Levels of COVID-19 According to the Clinical Course.
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 2 |
| SCOPUS | 2 |
| Google Scholar | 2 |