Investigation of virulence factors in seudomonas aeruginosa isolates by phenotypic and genotypic methods
Yazarlar (4)
Erhan Özsoy
Türkiye
Türkiye
Prof. Dr. Umut Safiye ŞAY COŞKUN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Öğr. Gör. Yelda DAĞCIOĞLU Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Osman DEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (Q4) | ||
| Dergi ISSN | 1525-7770 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2024 |
| Cilt / Sayı / Sayfa | 43 / 4 / 292–301 | DOI | 10.1080/15257770.2023.2254346 |
| Makale Linki | https://doi.org/10.1080/15257770.2023.2254346 | ||
| Özet |
| A total of 80 strains were sent from various clinics included in the study. Identification and antibiotic resistance profile of isolates were determined by Vitek 2 (Biomerioux, France) automated system. P agar, F agar, and motility test medium were used for phenotyping tests. , , , and were evaluated with Real-time PCR (Anatolia, Geneworks, Turkey). The highest rates of antibiotic resistance were observed against imipenem (42.5%) and meropenem (40%). Among the isolates, 81.3% tested positive for , 30% for , 32.5% for , and 42.5% for . Additionally, 70.4% of the isolates tested positive for pyocyanin, 41.3% for pyoverdine, 1.8% for pyorubin, and 8.9% tested negative for pyorubin. No statistically significant difference was found between antibiotic resistance and the presence of virulence factors ( > 0.005). The relationship between antibiotic resistance and virulence factors is controversial. There are studies demonstrating the relationship between virulence factors and antibiotic resistance, as well as studies that indicate the absence of such a relationship. Investigating virulence and antibiotic resistance rates may be important for identifying potential drug targets for subsequent research. |
| Anahtar Kelimeler |
| Pseudomonas aeruginosa | exotoxin A | exoenzym S | phospholipase C | elastas |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |