Effects of ketamine on penile tissues in an experimental priapism model in rats
Yazarlar (9)
Dr. Öğr. Üyesi Vildan KÖLÜKÇÜ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Mehtap GÜRLER BALTA Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Hakan TAPAR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Tuğba KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serkan KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Velid Unsal Mardin Artuklu Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Kenan YALÇIN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fatih FIRAT Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Ulusal Travma ve Acil Cerrahi Dergisi (Q3) | ||
| Dergi ISSN | 1306-696X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2024 |
| Cilt / Sayı / Sayfa | 30 / 5 / 309–315 | DOI | 10.14744/tjtes.2024.33262 |
| Özet |
| BACKGROUND: This study aimed to evaluate the histopathological and biochemical effects of ketamine on penile tissues following ischemia-reperfusion injury induced by priapism. METHODS: Twenty-four male rats were randomized into three groups. Group 1 served as the control group. Group 2 underwent the priapism model to induce ischemia-reperfusion injury. Group 3, the treatment group, experienced a similar ischemia-reperfusion model as Group 2; additionally, 50 mg/kg of ketamine was administered intraperitoneally just before reperfusion. Blood biochemical analyses and penile histopathological evaluations were performed. RESULTS: In Group 3, significant improvements were observed in all histopathological scores, including desquamation, edema, inflammation, and vasocongestion compared to Group 2 (p<0.001). Blood biochemical analyses showed that the malondialdehyde (MDA) levels were recorded as 10 in Group 2, with a significant decrease in Group 3 (p=0.013). Similarly, proinflammatory cytokine levels, including interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), were found to be suppressed in Group 3 compared to Group 2 (p=0.003, p=0.022, and p=0.028, respectively). Antioxidant enzyme activities, such as glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), were higher in Group 3 compared to Group 2 (p=0.016 and p=0.024, respec- tively). CONCLUSION: Ketamine is an effective anesthetic agent in alleviating the effects of penile ischemia-reperfusion injury. |
| Anahtar Kelimeler |
| Anesthesia | ischemia-reperfusion | ketamine | penis. |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |