Wingless ligands and beta‐catenin expression in the rat endometrium: The role of Wnt3 and Wnt7a/beta‐catenin pathway at the embryo–uterine interface
Yazarlar (7)
Prof. Dr. Celal Kaloğlu Sivas Cumhuriyet Üniversitesi, Türkiye
Hüseyin Eray Bulut Türkiye
Dr. Öğr. Üyesi Rasim Hamutoğlu Sivas Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Ertan Mahir Korkmaz Sivas Cumhuriyet Üniversitesi, Türkiye
Ozan Önder
Dr. Öğr. Üyesi Tuğba DAĞDEVİREN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Merve Nur Aydemir İstanbul Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | MOLECULAR REPRODUCTION AND DEVELOPMENT (Q3) | ||
| Dergi ISSN | 1040-452X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 11-2020 |
| Cilt / Sayı / Sayfa | 87 / 11 / 1159–1172 | DOI | 10.1002/mrd.23423 |
| Makale Linki | https://doi.org/10.1002/mrd.23423 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| Wnt/beta‐catenin signaling may play an essential role in endometrial decidualization, placentation, and the establishment of pregnancy. We investigate here the possible roles, immunolocalizations, and synthesis of the Wnt3, Wnt7a, and beta‐catenin proteins in the rat endometrium during the estrous cycle and early postimplantation period. Wnt3 and Wnt7a had a similar localization and dynamic expression relative to the endometrial stages. Wnt7a immunostaining was not limited only to the luminal epithelial cells, but also to strong stainings in the stromal and endothelial cells. Wnt3, Wnt7a, and beta‐catenin were highly synthesized and colocalized at the trophoblast‐decidual interface; and were more obvious in the primary decidual zone, the GTCs, and the ectoplacental cone. Beta‐catenin was strongly localized at the borders of the mature decidual cells; however, Wnt3 and Wnt7a immunolocalizations were … |
| Anahtar Kelimeler |
| decidualization | immunofluorescence | implantation | real-time PCR | Wnt |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Google Scholar | 12 |