The regulation of trophoblast invasion and decidual reaction by matrix metalloproteinase‐2, metalloproteinase‐7, and metalloproteinase‐9 expressions in the rat endometrium
Yazarlar (7)
Dr. Öğr. Üyesi Rasim Hamutoğlu Sivas Cumhuriyet Üniversitesi, Türkiye
Hüseyin Eray Bulut
Sivas Cumhuriyet Üniversitesi, Türkiye
Sivas Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Celal Kaloğlu Sivas Cumhuriyet Üniversitesi, Türkiye
Ozan Önder
Dr. Öğr. Üyesi Tuğba DAĞDEVİREN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Merve Nur Aydemir İstanbul Üniversitesi, Türkiye
Prof. Dr. Ertan Mahir Korkmaz Sivas Cumhuriyet Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Reproductive Medicine and Biology (Q2) | ||
| Dergi ISSN | 1445-5781 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 08-2020 |
| Kabul Tarihi | 13-07-2020 | Yayınlanma Tarihi | 06-08-2020 |
| Cilt / Sayı / Sayfa | 19 / 4 / 385–397 | DOI | 10.1002/rmb2.12342 |
| Makale Linki | https://doi.org/10.1002/rmb2.12342 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| Purpose We aimed to evaluate how matrix metalloproteinases (MMPs) regulate the trophoblast invasion and placentation. Methods Female rats were divided into the estrous cycle and early pregnancy day groups. Obtained uterine tissues and implantation sites were processed for immunofluorescence and real‐time PCR examinations. Results The mRNA expression of MMP‐7 was higher than MMP‐2 and MMP‐9. Immunofluorescence findings confirmed that MMP‐2, MMP‐7, and MMP‐9 were localized in the endometrial stroma, while MMP‐7 was high in glandular and lining epithelial cells throughout the entire estrous cycle. However, their immunolocalizations and mRNA expressions were dramatically changed with the early pregnancy days. The MMP‐7 reached very strong immunostaining in the giant trophoblast cells (GTCs), and the cytoplasm of mature and differentiating decidual cells, whereas MMP‐2 … |
| Anahtar Kelimeler |
| decidualization | implantation | MMP | Real-time PCR | trophoblast invasion |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 4 |
| Web of Science | 25 |
| Google Scholar | 40 |
| PubMed | 15 |