Evaluation of the Efficacy of Colchicine, Pirfenidone and Prednisolone in Preventing Stricture Due to Inflammation as a Result of Urethral Mucosal Damage in Rats
Yazarlar (4)
Doç. Dr. Fatih FIRAT
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Kenan YALÇIN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret ERDEMİR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Urological Surgery |
| Dergi ISSN | 2148-9580 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | WoS Emerging Sources Citation Index (ESCI) |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2025 |
| Cilt No | 12 |
| Sayı | 1 |
| Sayfalar | 40 / 48 |
| DOI Numarası | 10.4274/jus.galenos.2025.2024-12-6 |
| Makale Linki | https://jurolsurgery.org/ |
| Özet |
| Objective: To evaluate the effectiveness of oral use of drugs with anti-inflammatory and antifibrotic properties that are used in the treatment of many diseases in clinical practice in rats with stenosis caused by urethral damage. Materials and Methods: Forty male rats were equally divided into 5 groups. After anesthesia, penectomy was performed in group 1 without any other procedure. Urethral stenosis was created in rats in the groups 2, 3, 4, and 5. The rats in group 2 underwent penectomy at the end of 6 weeks. Groups 3, 4, and 5 were treated with colchicine, prednisolone, and pirfenidone, respectively by gavage for 6 weeks and underwent penectomy. Inflammation, fibrosis, and urethral lumen area were evaluated histopathologically in urethral tissue or all animals. Results: The urethral lumen area increased in group 4, although this incease was not statistically significant compared to group 2. In addition, prednisolone lead to a significant decrease in the inflammation and fibrosis scores compared to group 2. We also found that there was a significant decrease in inflammation and fibrosis scores and a significant increase in the urethral lumen area in groups 3,5 compared to group 2. Moreover, the group 3 had a significant increase in matrix metalloproteinase-9 expression compared to group 2. Bone morphogenetic protein-2 expression was increased especially in groups 3,5. Conclusion: We concluded that oral administration of colchicine or pirfenidone prevented the formation of urethral stenosis in rats to a large extent. The oral steroid treatment also reduced the formation of urethral stenosis, although not as effectively as colchicine or pirfenidone. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |