Antioxidant, and enzyme inhibition effects of chia (Salvia hispanica) seed oil: A comprehensive phytochemical screening using LC-HR/MS
Yazarlar (8)
Muzaffer Mutlu İstanbul Gelişim Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynebe BİNGÖL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Eda Mehtap Ozden
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Ekrem Köksal Erzincan Binali Yıldırım Üniversitesi, Türkiye
Adem Erturk Atatürk Üniversitesi, Türkiye
Ahmet C. Goren
Gebze Teknik Üniversitesi, Türkiye
Gebze Teknik Üniversitesi, Türkiye
Saleh Alwasel
College Of Sciences, Suudi Arabistan
College Of Sciences, Suudi Arabistan
İlhami Gulcin Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Electronic Journal of Biotechnology (Q3) | ||
| Dergi ISSN | 0717-3458 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2025 |
| Cilt / Sayı / Sayfa | 74 / 1 / 41–53 | DOI | 10.1016/j.ejbt.2024.12.002 |
| Makale Linki | https://doi.org/10.1016/j.ejbt.2024.12.002 | ||
| Özet |
| Background: In this study, the antioxidant and anti-Alzheimer's disease properties of Chia (Salvia hispanica) seed oil (CSO) were determined for the first time. Three different metal reduction and two different radical scavenging methods were used to determine the antioxidant properties of CSO. It exhibited higher antioxidant activity than vitamins E and C in the CUPRAC method. Results: CSO has shown excellent efficacy in the antioxidant methods used in this study. In the DPPH radical scavenging method, CSO exhibited higher radical scavenging potential than BHT, a standard and synthetic antioxidant. The anti-Alzheimer's disease properties of CSO were determined by inhibition of acetylcholinesterase enzyme and its IC50 value (17.60 µg/mL) was found to be close to the IC50 value of tacrine (8.82 µg/mL), the standard inhibitor of the enzyme. Inhibition properties of α-glycosidase enzyme and human carbonic anhydrase II isoenzymes were also studied. It was understood that CSO inhibited both enzymes at a lower rate than standard inhibitors. Also, the total phenolic and flavonoid contents of CSO were determined as 784.44 µg gallic acid equivalent (GAE)/mL oil and quercetin 150.00 µg QE)/mL oil, respectively. In addition, LC-HRMS chromatography application was performed to understand the phenolic content of CSO. It was determined that isosakuranetin (29.07 mg/L oil) was the most abundant polyphenolic compound in CSA. Also, seven polyphenolics of the studied remained below the detectable amount. Conclusions: It was found that CSO had effective antioxidant activity, polyphenolic contents and potent enzyme inhibition properties, associated with some global disease. How to cite: Mutlu M, Bingol Z, Ozden EM, et al. Antioxidant, and enzyme inhibition effects of chia (Salvia hispanica) seed oil: A comprehensive phytochemical screening using LC-HR/MS. Electron J Biotechnol 2025;74. https://doi.org/10.1016/j.ejbt.2024.12.002. |
| Anahtar Kelimeler |
| Anti-Alzheimer properties | Antioxidant | Antioxidant activity | Chia | Enzyme inhibition | LC-HRMS | Phytochemical screening | Polyphenols | Salvia hispanica | Seed oil |
Science Direct
Antioxidant, and enzyme inhibition effects of chia (Salvia hispanica) seed oil: A comprehensive phytochemical screening using LC-HR/MS
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 8 |
| SCOPUS | 9 |
| Google Scholar | 9 |