Unveiling the role of miRNA in laryngeal squamous cell carcinoma progression: a retrospective study
Yazarlar (4)
Dr. Öğr. Üyesi Nejmiye AKKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Elif KAYA ÇELİK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Süleyman ÖZDEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Emrah SAPMAZ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (Q1) | ||
| Dergi ISSN | 0937-4477 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 282 / 7 / 3683–3688 | DOI | 10.1007/s00405-025-09306-y |
| Makale Linki | https://doi.org/10.1007/s00405-025-09306-y | ||
| Özet |
| MicroRNAs (miRNAs) have emerged as promising biomarkers for diagnosis and prognosis in laryngeal squamous cell carcinoma (LSCC). This study investigates the expression patterns of specific cancer-associated miRNAs in early and advanced stage LSCC to evaluate their potential role in disease progression. The expression levels of miRNA-21, miRNA-802, miRNA-29 and miRNA-9 were analysed in formalin-fixed paraffin-embedded (FFPE) tissues from 44 LSCC patients (20 early stage, 24 advanced stage) using quantitative multiplex RT-PCR. Tissue samples were analysed retrospectively. The expression level of hsa-miR-9a expression was significantly upregulated (5.2-fold) in advanced stage patients compared to the early stage group (p = 0.0088). Similarly, hsa-miR-802a showed significantly higher expression (9.2-fold) in advanced stage patients compared to early stage patients (p = 0.005). No significant differences in miRNA-21 and miRNA-29 expression levels were observed between the groups. As a result of the study, elevated miRNA levels in advanced stage patients can be used in targeted therapy and evaluated as a treatment option in LSCC patients. |
| Anahtar Kelimeler |
| LSCC | miRNA-21 | miRNA-802 | miRNA-29 | miRNA-9 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |