The evaluation of two genetic polymorphisms of paraoxonase 1 in patients with pulmonary embolism ....
Yazarlar (7)
Nurşah Başol Kaya Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Aslı Yasemen Savas
Dr. Öğr. Üyesi Kayhan KARAKUŞ Türkiye
İlker Kaya
Prof. Dr. Serhat KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Clinical Laboratory Analysis (Q3) | ||
| Dergi ISSN | 0887-8013 Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2018 |
| Kabul Tarihi | 26-03-2018 | Yayınlanma Tarihi | 22-04-2018 |
| Cilt / Sayı / Sayfa | 32 / 7 / 22455– | DOI | 10.1002/jcla.22455 |
| Makale Linki | http://doi.wiley.com/10.1002/jcla.22455 | ||
| UAK Araştırma Alanları |
Çocuk Radyolojisi
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| Özet |
| Background and ObjectivePulmonary embolism (PE) is caused by some genetic factors for more than half patients. Paraoxonase 1 (PON1) has significant anti‐oxidative and anti‐inflammatory effects. According to our knowledge, there is no study researching the relation between PON 1 gene polymorphisms and PE in the literature. Therefore, it is aimed to research possible impacts of PON 1 Q192R and L55M polymorphisms on PE, considering anti‐inflammatory and anti‐oxidative effects of PON 1 in Turkish population.MethodsOne hundred and five PE patients and one hundred and seventeen controls were enrolled in this study. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses for the PON1 gene Q192R and L55M polymorphisms.ResultsAny associations were not found between clinical and demographical characteristics of PE patients and the PON1 gene Q192R polymorphism; however, there were associations between surgery, chronic renal failure, and cerebrovascular disease on the history of patients and L55M polymorphism (P = .013, P = .037, and P = .031, respectively). Genotype and allele frequencies did not show any significant differences between patients and controls according to PON1 gene Q192R and L55M polymorphisms (P > .05).ConclusionThe results of this study suggest that there is no correlation between PE and PON 1 gene Q192R and L55M polymorphisms in the Turkish population from the Central Black Sea region. Besides, whole genotypes and alleles of Q192R and L55M are not risk factors for patients with PE in this population. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 3 |