Synthesis, Bioactivities, and in Silico Studies of Novel Benzo[d][1,3]Dioxole-Based Pyrazoline Sulfonamides
Yazarlar (7)
Doç. Dr. Mehtap TUĞRAK SAKARYA Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Halise İnci Gül Atatürk Üniversitesi, Türkiye
Doç. Dr. Cem Yamalı Çukurova Üniversitesi, Türkiye
Hiroshi Sakagami
Dr. Öğr. Üyesi Rüya Sağlamtaş Türkiye
Prof. Dr. Yusuf Sert Yozgat Bozok Üniversitesi, Türkiye
Prof. Dr. İlhami Gülçin Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Polycyclic Aromatic Compounds (Q2) | ||
| Dergi ISSN | 1040-6638 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 05-2025 |
| Cilt / Sayı / Sayfa | 45 / 9 / – | DOI | 10.1080/10406638.2025.2498144 |
| Makale Linki | https://doi.org/10.1080/10406638.2025.2498144 | ||
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Farmasotik Kimya
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| Özet |
| In this study, benzo[d][1, 3]dioxole-based pyrazoline sulfonamides were investigated for their biological effects on carbonic anhydrases (CAs), acetylcholinesterase (AChE), and the growth of cancer/noncancer cell lines. The synthesized 11 compounds were tested for cytotoxic efficacy against four human OSCC cell lines (Ca9-22, HSC-2, HSC-3, HSC-4) and three human normal oral cells (HGF, HPLF, and HPC). The CC50 values were in the range of 9.6–28.1 µM (toward Ca9-22), 10.3–44.0 µM (HSC-2), 8.6–32.1 µM (HSC-3) and 7.7–29.5 µM (HSC-4). All of these compounds showed reduced viable cell number of all oral cancer cells dose-dependently and ultimately killed them at the higher concentration (25 ∼ 100 µM), in contrast to the reference compound 5-FU that showed cytostatic growth inhibition without killing out even at the highest concentration (1000 µM). Among the series, compounds 7 (TS … |
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| Google Scholar | 6 |