Alpha-1 Antitrypsin Genotype Distribution in Patients with Emphysema
Yazarlar (5)
Levent Özdemir Samsun Üniversitesi, Türkiye
Savaş Gegin
Samsun Training And Research Hospital, Türkiye
Samsun Training And Research Hospital, Türkiye
Burcu Özdemir Samsun Training And Research Hospital, Türkiye
Esra Arslan Aksu Samsun Üniversitesi, Türkiye
Prof. Dr. Ahmet Cemal PAZARLI Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | International Journal of Copd (Q2) | ||
| Dergi ISSN | 1176-9106 | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2025 |
| Kabul Tarihi | 02-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 20 / 1 / 2815–2822 | DOI | 10.2147/COPD.S531347 |
| Makale Linki | https://doi.org/10.2147/copd.s531347 | ||
| Özet |
| PurposeAlpha-1 antitrypsin deficiency (AATD) is a rare inherited condition characterized by low serum levels of alpha-1 antitrypsin (AAT). In this study, we aimed to determine the frequency of AATD in patients with emphysema, to show the distribution of AATD genotypes according to the type and localization of emphysema, and to evaluate patients in terms of augmentation therapy.Patients and MethodsThis cross-sectional descriptive study included 794 patients with emphysema on high-resolution thoracic tomography (HRCT) between December 2022 and December 2024 at the chest disease clinic of the Samsun Training and Research Hospital. During screening, demographic characteristics (age and sex), smoking status (smoker, ex-smoker, and non-smoker), types of emphysema (centriacinar emphysema, panacinar emphysema, and paraseptal emphysema), and location (upper, middle, and lower lobes) were … |
| Anahtar Kelimeler |
| alpha-1 antitrypsin | augmentation therapy | emphysema | genotype |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |
| Scopus | 1 |
| Web of Science | 1 |