Neuroprotective effects of resveratrol and sodium valproate in penicillin-induced epilepsy model
Yazarlar (3)
Dr. Öğr. Üyesi Elif Azize ÖZŞAHİN DELİBAŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynep ACUNGİL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Metabolic Brain Disease (Q2) | ||
| Dergi ISSN | 0885-7490 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 40 / 6 / 1–14 | DOI | 10.1007/s11011-025-01667-x |
| Makale Linki | https://link.springer.com/article/10.1007/s11011-025-01667-x | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| This study investigated resveratrol's (RSV) neuroprotective properties in a penicillin-mediated epilepsy model, focusing on its anti-oxidation, anti-inflammatory, and anti-apoptotic properties, as well as its potential molecular interactions with an anti-epileptic drug sodium valproate (VPA). Thirty-two Wistar albino rats were divided into 4 groups; (PG) Penicillin 500 IU (2.5 µL, i.c.), (RG) RSV 40 mg/kg (i.p.) + Penicillin 500 IU (2.5 µL, i.c.), (SVG) Sodium VPA 300 mg/kg (i.p.) + Penicillin 500 IU (2.5 µL, i.c.), and (RSVG) RSV 40 mg/kg (i.p.) + Sodium VPA 300 mg/kg (i.p.) + Penicillin 500 IU (2.5 µL, i.c.). Anti-oxidation/anti-inflammatory aspects of RSV were evaluated by measuring malondialdehyde (MDA), protein carbonyl compounds (PCC), high mobility group box-1 (HMGB1), and nuclear factor-κappaB (NF-κB) levels using the ELISA method. Apoptosis in epilepsy was determined using the TUNEL method ... |
| Anahtar Kelimeler |
| Apoptosis | Epilepsy | High mobility group box-1 | Malondialdehyde | Nuclear factor-κappaB | Resveratrol |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 4 |
| Google Scholar | 4 |
| PubMed | 4 |