Tumor-specific cytotoxicity of pyrazole-based chalcone derivatives in human oral squamous cell carcinoma cell lines
Yazarlar (6)
Doç. Dr. Mehtap TUĞRAK SAKARYA
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
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| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Turkish Journal of Biology |
| Dergi ISSN | 1300-0152 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2025 |
| Cilt No | 49 |
| Sayfalar | 712 / 727 |
| DOI Numarası | 10.55730/1300-0152.2773 |
| Makale Linki | https://doi.org/10.55730/1300-0152.2773 |
| Özet |
| Background: Pyrazole-based chalcone hybrids are notable in medicinal chemistry for their potential biological activity. Their tumor-specific cytotoxicity and mechanisms remain unknown in OSCC cells. This is the first study of pyrazole–chalcone hybrids in OSCC cells. This study explores the tumor-selective cytotoxic effects and the underlying cell death mechanisms triggered by a series of ten newly synthesized pyrazole-based compounds (MS1–MS10) in OSCC cell lines.Material and methods: The cytotoxic effects of the compounds were assessed using the MTT assay on four human OSCC cell lines and three types of normal human oral cells. Tumor-selectivity index (TS) and Potency-selectivity expression (PSE) were calculated. Active compounds were subjected to cell cycle analysis. For QSAR modeling, 3,096 descriptors comprising physicochemical, structural, and quantum chemical features were created using … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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