Antioxidant Activity and Phytochemical Profiling of Steam-Distilled Oil of Flaxseed (Linum usitatissimum): Therapeutic Targeting Against Glaucoma, Oxidative Stress, Cholinergic Imbalance, and Diabetes
Yazarlar (7)
İlhami Gulcin Atatürk Üniversitesi, Türkiye
Muzaffer Mutlu İstanbul Gelişim Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynebe BİNGÖL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Eda Mehtap Ozden
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Ziba Mirzaee
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Ahmet C. Goren
Gebze Teknik Üniversitesi, Türkiye
Gebze Teknik Üniversitesi, Türkiye
Ekrem Köksal Erzincan Binali Yıldırım Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Molecules (Q2) | ||
| Dergi ISSN | 1420-3049 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2025 |
| Cilt / Sayı / Sayfa | 30 / 16 / 3384–3392 | DOI | 10.3390/molecules30163384 |
| Makale Linki | https://www.scopus.com/pages/publications/105014358673 | ||
| Özet |
| This investigation explored the chemical constituents and biological activities of the steam-distilled oil of (SDOLU), employing sophisticated techniques including LC-HRMS, GC-MS, and GC-FID. The analysis identified a diverse array of 17 phenolic compounds, with linoleoyl chloride (64.05%) and linoleic acid (10.39%) as the major fatty acid components. The SDOLU demonstrated remarkable antioxidant capacity, effectively neutralizing free radicals in both DPPH (IC: 19.80 μg/mL) and ABTS (IC: 57.75 μg/mL) scavenging assays, alongside robust electron-donating activity in reducing ability tests. Moreover, the SDOLU showed significant inhibition of key enzymes implicated in metabolic and neurodegenerative disorders, including α-amylase (IC: 531.44 μg/mL), acetylcholinesterase (IC: 13.23 μg/mL), and carbonic anhydrase II (IC: 281.02 μg/mL). Collectively, these results highlight the SDOLU as a valuable natural source of multifunctional bioactivities with potential applications in combating oxidative stress and enzyme-related global diseases. Further studies are warranted to validate its therapeutic efficacy and expand its industrial utilization. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 4 |
| SCOPUS | 4 |
| Google Scholar | 2 |