LC-ESI-MS/MS Profiling and In Vitro Evaluation of Antioxidant, Enzymatic Inhibitory, and Cytotoxic Activities, Along With Complementary In Vitro and In Silico Assessment of the Antibacterial Potential of Centaurea papposa Leaf Extracts
Yazarlar (9)
Jihane Bounaas Université 20 Août 1955-Skikda, Cezayir
Abdelkader Basli Université 20 Août 1955-Skikda, Cezayir
Ismahan Ounissi Université 20 Août 1955-Skikda, Cezayir
Sarah Rahal Université Badji Mokhtar - Annaba, Cezayir
Samia Benzazia Université 20 Août 1955-Skikda, Cezayir
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. İlyas YILDIZ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tevfik Ozen Ondokuz Mayis Üniversitesi, Türkiye
Sarmad Marah Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistry and Biodiversity (Q3) | ||
| Dergi ISSN | 1612-1872 Dergi Bilgileri (2025) | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2025 |
| Cilt / Sayı / Sayfa | 22 / 12 / – | DOI | 10.1002/cbdv.202501232 |
| Makale Linki | https://doi.org/10.1002/cbdv.202501232 | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| The main objective of this study was to characterize the phenolic composition of the hydromethanolic extract and its fractions from Centaurea papposa leaves, and to evaluate their antioxidant, enzymatic inhibitory, cytotoxic, and antibacterial activities. In addition, molecular docking analysis was performed using dihydropteroate synthase as the bacterial target enzyme to explore the interactions with major phenolic compounds. LC‐MS/MS analysis identified shikimic acid and chlorogenic acid as predominant in the hydromethanolic extract. In the ethyl acetate fraction, vanillic acid, protocatechuic acid, chlorogenic acid, and shikimic acid were the major constituents. Meanwhile, the chloroform fraction was rich in salicylic acid and luteolin. Furthermore, the antioxidant assays, including 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS+), ferric reducing power (FRAP … |
| Anahtar Kelimeler |
| antibacterial activity | antioxidant activity | Centaurea papposa | cytotoxic activity | LC-MS/MS analysis | molecular docking |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |
| PubMed | 1 |