LC-ESI-MS/MS-based phytochemical profiling and pharmacological validation of Centaurium erythraea Rafn (Gentianaceae) traditionally used for pain and inflammation
Yazarlar (9)
Sarra Chabane University Mohamed Boudiaf Of M‘Sila, Cezayir
Amel Boudjelal University Mohamed Boudiaf Of M‘Sila, Cezayir
İbrahim Demirtaş Ondokuz Mayıs Üniversitesi, Türkiye
Souheila Bouchahdane Université Badji Mokhtar - Annaba, Cezayir
Ghania Tail Université Blida 1, Cezayir
Semiha Yenigün
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Tevfik Özen Ondokuz Mayıs Üniversitesi, Türkiye
Doç. Dr. İlyas YILDIZ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Abdeltif Amrane Ecole Nationale Supérieure De Chimie De Rennes, Fransa
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Ethnopharmacology (Q1) | ||
| Dergi ISSN | 1872-7573 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2026 |
| Cilt / Sayı / Sayfa | 360 / 1 / 121135–0 | DOI | 10.1016/j.jep.2025.121135 |
| Makale Linki | https://doi.org/10.1016/j.jep.2025.121135 | ||
| Özet |
| Ethnopharmacological relevanceThese findings provide scientific support for the traditional use of Centaurium erythraea Rafn (Gentianaceae) in Algerian folk medicine and suggest its potential for further pharmacological exploration in the management of pain and neuroinflammatory conditions.Aim of the studyThe present study aimed to scientifically validate these traditional uses through phytochemical profiling and pharmacological evaluation of the aqueous extract (C. erythraea aqueous extract, CEAE).Materials and methodsThe polyphenolic composition was characterized, and in vitro antioxidant and DNA protection activities, enzyme inhibitory effects, as well as in vivo analgesic activity using the acetic acid–induced writhing and hot plate tests, in addition to acute oral toxicity, and molecular docking studies were evaluated.ResultsLC-ESI-MS/MS analysis revealed the presence of several phenolic and flavonoid … |
| Anahtar Kelimeler |
| Centaurium erythraea | Acute toxicity | Antioxidant activity | Cholinesterase inhibition | DNA protection | Analgesic effect |
Science Direct
LC-ESI-MS/MS-based phytochemical profiling and pharmacological validation of Centaurium erythraea Rafn (Gentianaceae) traditionally used for pain and inflammation
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