Metabolite Profiling and Bioactivity of Eastern Algerian Posidonia oceanica: Cholinesterase and Urease Inhibition with Low Cytotoxicity
Yazarlar (12)
Malaoui Karima Université Oum El Bouaghi, Cezayir
Karouche Saida Université Oum El Bouaghi, Cezayir
Ouided Benslama Université Oum El Bouaghi, Cezayir
Hamdi Bendif Imam Mohammad Ibn Saud Islamic University, Suudi Arabistan
Sabrina Lekmine Université Abbes Laghrour Khenchela, Cezayir
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dib Mouna Université Oum El Bouaghi, Cezayir
Lamjed Bouslama Université De Tunis El Manar, Tunus
Sulaiman A Alsalamah Imam Mohammad Ibn Saud Islamic University, Suudi Arabistan
Tarek H. Taha Imam Mohammad Ibn Saud Islamic University, Suudi Arabistan
Fehmi Boufahja Imam Mohammad Ibn Saud Islamic University, Suudi Arabistan
Stefania Garzoli Sapienza Università Di Roma, İtalya
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | ACS Omega (Q2) | ||
| Dergi ISSN | 2470-1343 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2025 |
| Cilt / Sayı / Sayfa | 10 / 40 / 47655–47675 | DOI | 10.1021/acsomega.5c08586 |
| Makale Linki | https://doi.org/10.1021/acsomega.5c08586 | ||
| UAK Araştırma Alanları |
Organik Kimya
Nanoteknoloji
Biyokimya
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| Özet |
| Given the growing need for sustainable and natural alternatives to address global health and environmental challenges, marine plants have emerged as promising sources of bioactive compounds. In this context, the present study aimed to investigate the therapeutic potential of Posidonia oceanica (L.) Delile through chemical profiling and enzymatic inhibitory evaluation. Samples (leaves and rhizomes) were collected from the eastern Algerian coast in 2023. Methanolic extracts were prepared and analyzed using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). The inhibitory activity of the extracts was evaluated against three key enzymes: urease, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE), using Ellman’s colorimetric method for AChE and BChE, and the indophenol-based colorimetric method for urease. Cytotoxicity was assessed using the MTT colorimetric assay … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Scopus | 5 |
| Google Scholar | 7 |