Effect of perinatal nicotine exposure on oxidative stress and BDNF levels in the brain tissue of offspring rats: The protective role of Vitamin E
Yazarlar (9)
Beyza Guzide Ozerol
Engin Burak Selcuk
Elif Gurel
Muhammed Mehdi Uremis
Mehmet Gul
Dr. Öğr. Üyesi Semir GÜL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Harika Gozde Gozukara Bag
Onural Ozhan
Yusuf Turkoz
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | TISSUE & CELL (Q1) | ||
| Dergi ISSN | 0040-8166 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2025 |
| Cilt / Sayı / Sayfa | 95 / 0 / 102881–0 | DOI | 10.1016/j.tice.2025.102881 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0040816625001612 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| ObjectiveNicotine, a well-known neurotoxin, induces oxidative stress in fetal tissues, leading to organ damage and fetal growth retardation. This study aims to evaluate oxidative stress parameters in the brain tissue of rat offspring exposed to perinatal nicotine and assess vitamin E's protective effects.MethodsTwenty-five pregnant rats were administered 10 mg/L of nicotine and 300 mg/L of Vitamin E in drinking water starting from the first day of gestation. On gestational day 21, some offspring were euthanized to form the prenatal group. The remaining litters were born naturally, and dams received treatments via drinking water during gestation and lactation (6 weeks). After the lactation period, the pups were weaned and directly treated for an additional 9 weeks, resulting in an overall treatment duration of 15 weeks. Brain tissues were analyzed for MDA, GSH, TOS, TAS, OSI, BDNF, Caspase-3 activity, and … |
| Anahtar Kelimeler |
| Nicotine | Rats | Brain | Oxidative Stress | Vitamin E | Brain-Derived Neurotrophic Factor |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Google Scholar | 2 |