Possible therapeutic effects of PROK2 in testicular ischemia/reperfusion injury: A preclinical study in Wistar albino rats
Yazarlar (5)
Ilayda Uysal
Nesibe Yilmaz
Dr. Öğr. Üyesi Semir GÜL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Kevser Tanbek
Umit Yilmaz
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | TISSUE & CELL (Q1) | ||
| Dergi ISSN | 0040-8166 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2025 |
| Cilt / Sayı / Sayfa | 93 / 0 / 102778–0 | DOI | 10.1016/j.tice.2025.102778 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0040816625000588 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| This study aimed to investigate the therapeutic effects of PROK2 on oxidative stress, inflammatory response, and tissue damage caused by ischaemia/reperfusion (I/R) in testicular tissue. A total of 48 prepubertal male Wistar albino rats were divided into four groups: sham, testicular torsion/detorsion (TTD), testicular torsion + PROK2 + detorsion (TT + PROK2 + TD), and testicular torsion/detorsion + PROK2 (TTD + PROK2) (n = 12). Testicular torsion/detorsion surgeries (2 hours of torsion followed by 24 hours of detorsion) were performed on all groups except the sham group. The TT + PROK2 + TD group received a single dose of PROK2 (60 nmol/kg) intraperitoneally 30 minutes before the end of torsion, while the TTD + PROK2 group received a single dose of PROK2 (60 nmol/kg) at the beginning of detorsion. Subsequently, biochemical parameters (serum testosterone level, total antioxidant capacity … |
| Anahtar Kelimeler |
| PROK-2 | Torsion/detorsion | Oxidative stress | Inflammation | Histomorphometry |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |