Phoenixin-14 may ameliorate testicular damage caused by torsion-detorsion by reducing oxidative stress and inflammation in prepubertal rats
Yazarlar (3)
Nesibe Yilmaz
Jemal Hudaykuliyeva
Dr. Öğr. Üyesi Semir GÜL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | TISSUE & CELL (Q1) | ||
| Dergi ISSN | 0040-8166 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2024 |
| Cilt / Sayı / Sayfa | 88 / 0 / 102405–0 | DOI | 10.1016/j.tice.2024.102405 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S004081662400106X | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| The present study aimed to investigate the effects of Phoenixin-14 (PNX-14) on oxidative damage, inflammatory response, histopathological variations, and serum testosterone levels in testicular tissues. Forty-eight Wistar albino prepubertal male rats were divided into 4 groups (Sham, TTD, TT+PNX+TD, TTD+PNX) (n=12). The torsion period was 2 hours and the detorsion period was 24 hours in the testicular torsion/detorsion (TD) groups. A single PNX-14 (50 µg/kg) dose was injected into the rats in the TT+PNX TD group on the 90th minute of torsion, and it was injected into the rats in the TTD+PNX group at the beginning of detorsion. Oxidative damage in testicular tissues was determined based on superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS), and inflammatory damage was determined based on TNF-α and IL-6 levels. Histopathological … |
| Anahtar Kelimeler |
| Torsion/detorsion | Phoenixin-14 | Oxidative stress | Inflammation | Spermatogonia morphology |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 9 |
| Google Scholar | 10 |