Chalcone-based Pyrazoline Derivatives as Modulators of Neuroinflammatory and Redox Pathways in Experimental Epilepsy
Yazarlar (4)
Dr. Öğr. Üyesi Elif Azize ÖZŞAHİN DELİBAŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zeynep ACUNGİL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Esra Koc Tokat Gaziosmapasa University, Türkiye
Doç. Dr. Şeyma ÖZSOY Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Molecular Neurobiology (Q1) | ||
| Dergi ISSN | 0893-7648 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2026 |
| Cilt / Sayı / Sayfa | 63 / 1 / 507– | DOI | 10.1007/s12035-026-05795-y |
| Makale Linki | https://link.springer.com/article/10.1007/s12035-026-05795-y#citeas | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Epilepsy is a chronic neurological condition characterized by complex pathophysiological interactions involving oxidative stress (OS) and neuroinflammation. In this study, the neuroprotective effects of chalcone-based pyrazoline derivatives (CCA-326, CCA-334, CCD-326, and CCD-334) are investigated in a penicillin-induced epilepsy model in rats. The ELISE method is used to measure the effects of these compounds on the plasma and brain levels of cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), nuclear factor-kappa B (NF-κB), Kelch-like ECH-associated protein 1 (KEAP1), and nuclear factor erythroid 2-related factor 2 (NRF2). Total antioxidant status (TAS) and total oxidant status (TOS) were determined using colorimetric methods. CCA-326 and CCA-334 significantly reduces NF-κB, COX-2, and 5-LOX levels, increases NRF2 expression and TAS levels, and supports the activation of the endogenous … |
| Anahtar Kelimeler |
| 5-LOX | Chalcone | COX-2 | KEAP1- NRF2 | Neuroinflammation | Oxidative Stress |
BM Sürdürülebilir Kalkınma Amaçları
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| Web of Science | 1 |
| Google Scholar | 1 |