Unveiling the Bioactive Potential of Medicago lupulina Flowers: LC-ESI-MS/MS Phytochemical Profiling, Potentiometric Biosensor-Based Antioxidant Evaluation, and In Silico COX-2 Inhibition
Yazarlar (4)
Sena Tekeli Iğdır Üniversitesi, Türkiye
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. İlyas YILDIZ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Yunus Başar Iğdır Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Flavour and Fragrance Journal (Q3) | ||
| Dergi ISSN | 0882-5734 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 07-2026 |
| Cilt / Sayı / Sayfa | 41 / 4 / 988–1001 | DOI | 10.1002/ffj.70094 |
| Makale Linki | https://doi.org/10.1002/ffj.70094 | ||
| UAK Araştırma Alanları |
Organik Kimya
|
||
| Özet |
| Plants exhibit significant biological activity and are widely used in the pharmaceutical and food industries due to their bioactive compounds. Medicago lupulina is a plant species belonging to the Fabaceae family. In this study, dried flowers of M. lupulina were extracted with methanol. The total phenolic content and DPPH˙ radical scavenging activity of the obtained extract were determined using a potentiometric biosensor method. In addition, the phenolic content of the extract was determined by LC‐ESI‐MS/MS. The inhibitory properties of the main components against cyclooxygenase‐2 (COX2) were theoretically investigated using molecular docking. Moreover, the pharmacokinetic properties of the main molecules were determined by SwissADME. The methanol extract exhibited a DPPH radical scavenging activity of 39.43% and contained 117.2 mg GAE g−1 extract of total phenolics at 500 ppm. In the LC‐ESI … |
| Anahtar Kelimeler |
| antioxidant activity | biosensor | inhibitor | Medicago lupulina | phytochemical analysis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |