In vitro anticholinesterase activity and molecular docking studies of coumarin derivatives isolated from roots of Heptaptera cilicica
Yazarlar (6)
Prof. Dr. Hilal Özbek Atatürk Üniversitesi, Türkiye
Prof. Dr. Zühal Güvenalp Atatürk Üniversitesi, Türkiye
Doç. Dr. Gülderen YILMAZ Ankara Üniversitesi, Türkiye
Kadir Yerdelen
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Prof. Dr. Cavit Kazaz Atatürk Üniversitesi, Türkiye
Ömür L. Demirezer
Hacettepe Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Medicinal Chemistry Research | ||
| Dergi ISSN | 1054-2523 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2018 |
| Cilt / Sayı / Sayfa | 27 / 2 / 538–545 | DOI | 10.1007/s00044-017-2080-x |
| UAK Araştırma Alanları |
Farmasotik Botanik
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| Özet |
| The chloroform extract of the roots of Heptaptera cilicica (Boiss. & Bal.) Tutin (Apiaceae) was investigated in terms of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory effects by Ellman method. Afterwards, a new furocoumarin: trichoclin angelate with five known coumarin derivatives: umbelliprenin, badrakemone, badrakemin, badrakemin acetate and prunate were isolated from this extract. Their structures were identified by means of spectroscopic methods (1D, 2D-NMR and HRESIMS). The next step of our study was determining AChE and BuChE inhibitory activities of the compounds by molecular docking and in vitro methods. According to the results, prunate was found to be the most potent compound, which exhibited significant inhibitory potency against acetylcholinesterase (IC |
| Anahtar Kelimeler |
| AChE | Apiaceae | BuChE | Coumarin | Heptaptera cilicica |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 12 |
| Scopus | 14 |