Survey of 55 Turkish Salvia taxa for their acetylcholinesterase inhibitory and antioxidant activities
Yazarlar (7)
F. Sezer Şenol
Gazi Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Doç. Dr. Ilkay Orhan Gazi Üniversitesi, Türkiye
Ferhat Celep Middle East Technical University (Metu), Türkiye
Prof. Dr. Ahmet Kahraman Middle East Technical University (Metu), Türkiye
Musa Doǧan
Middle East Technical University (Metu), Türkiye
Middle East Technical University (Metu), Türkiye
Doç. Dr. Gülderen YILMAZ Ankara Üniversitesi, Türkiye
Bilge Şener
Gazi Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Food Chemistry | ||
| Dergi ISSN | 0308-8146 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2010 |
| Cilt / Sayı / Sayfa | 120 / 1 / 34–43 | DOI | 10.1016/j.foodchem.2009.09.066 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0308814609011261 | ||
| UAK Araştırma Alanları |
Farmasotik Botanik
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| Özet |
| In the current work, our target was to screen inhibitory potentials of 55 Turkish Salvia taxa, 28 of which are endemic, against acetylcholinesterase (AChE), which is a chief enzyme in pathogenesis of Alzheimer's disease (AD). The dichloromethane, ethyl acetate, and methanol extracts prepared from 55 Salvia taxa were tested for their AChE inhibitory activity at 25, 50, and 100 μg/ml using an ELISA microplate reader. The extracts were also screened for their scavenging effect against DPPH radical and iron-chelating capacity. Total phenol and total flavonoid contents of Salvia fruticosa were determined. Among the 165 Salvia extracts screened, only the dichloromethane extract of S. fruticosa showed inhibition towards AChE at 100 μg/ml having 51.07% of inhibition, while only the dichloromethane and ethyl acetate extracts of Salvia cilicica had a notable iron-chelating capacity at 100 μg/ml having 54.71% of chelating capacity. Most of the extracts showed remarkable scavenging effect against DPPH radical. © 2009 Elsevier Ltd. All rights reserved. |
| Anahtar Kelimeler |
| Acetylcholinesterase | Alzheimer's disease | DPPH radical scavenging activity | Iron-chelating effect | Salvia | Total flavonoid | Total phenol |
Science Direct
Survey of 55 Turkish Salvia taxa for their acetylcholinesterase inhibitory and antioxidant activities
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 120 |
| Scopus | 136 |