Phytochemical screening, biological evaluation, anatomical, and morphological investigation of Ferula tingitana L. (Apiaceae)
Yazarlar (13)
Prof. Dr. Songül Karakaya Atatürk Üniversitesi, Türkiye
Doç. Dr. Hafize Yuca Atatürk Üniversitesi, Türkiye
Doç. Dr. Gülderen YILMAZ Ankara Üniversitesi, Türkiye
Dr. Öğr. Üyesi Bilge Aydın Erzincan Binali Yıldırım Üniversitesi, Türkiye
Arş. Gör. Enes Tekman Atatürk Üniversitesi, Türkiye
Gülnur Ekşi
İstanbul Medipol Üniversitesi, Türkiye
İstanbul Medipol Üniversitesi, Türkiye
Prof. Dr. Mehmet Bona Istanbul Üniversitesi, Türkiye
Doç. Dr. Gamze Göger Afyokarahisar Health Sciences University, Türkiye
Doç. Dr. Mehmet Karadayı Atatürk Üniversitesi, Türkiye
Yusuf Gülşahin
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Gözde Öztürk Anadolu Üniversitesi, Türkiye
Prof. Dr. Betül Demirci Anadolu Üniversitesi, Türkiye
Prof. Dr. Zühal Güvenalp Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Protoplasma (Q2) | ||
| Dergi ISSN | 0033-183X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 06-2023 |
| Cilt / Sayı / Sayfa | 260 / 6 / 1581–1601 | DOI | 10.1007/s00709-023-01874-2 |
| Makale Linki | https://doi.org/10.1007/s00709-023-01874-2 | ||
| UAK Araştırma Alanları |
Farmasotik Botanik
|
||
| Özet |
| Ferula tingitana L. is a high perennial plant and its leaf is an alternate arrangement and yellow, and its flowers are unisexual like other Apiaceae. It has been used as a spice and for various medicinal purposes in the Mediterranean region. The paper reports antidiabetic, antimicrobial, anticholinesterase, antioxidant, and genotoxic activities of leaves, flowers, stems, and fruits methanol extracts of F. tingitana. Also, quantitative determination of some secondary metabolites was also analyzed by LC-MS/MS. Moreover, chemical composition of essential oils was analyzed. Consequently, anatomical, and morphological properties of plant were investigated. Germacrene D (23.6%), 1,3,5-trimethylbenzene (18.4%), and α-pinene (50.0%) were found as the main compounds in flower, leaf, and stem oils, respectively. The cortex in stem, pedicel, and fruit is characterized by angular collenchyma cells and a distinct cambium layer. 6 compounds (quinic acid, fumaric acid, keracyanin chloride, cyanidin-3-O-glucoside, chlorogenic acid, hesperidin) were observed in samples. Leaf extract showed anticholinesterase activity. Leaf and flower extracts showed the highest % inhibition value on ABTS·+ and DPPH•. Leaf extract has the strongest antioxidant effect because it is rich in total phenolic contents. All extracts of F. tingitana were found generally effective against C. albicans. Stem extract was found effective against E. coli and flower extract was found more effective against S. enterica and C. albicans. Bacterial genotoxicity results showed that extracts did not have genotoxic activity on tester strains S. typhimurium and E. coli WP2uvrA. Thus, it revealed that extracts were genotoxic-ally safe at applied concentrations up to 3 mg/plate. Graphical abstract: [Figure not available: see fulltext.] |
| Anahtar Kelimeler |
| Anatomical | Anticholinesterase | Antidiabetic | Antioxidant | Ferula tingitana | Morphological |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 15 |
| Scopus | 17 |