Phytochemical content and enzyme inhibitory effect of Heptaptera triquetra (Vent.) Tutin fruit against acetylcholinesterase and carbonic anhydrase I and II isoenzymes

Kaya, Ayşe Çiçek; Özbek, Hilal; Yuca, Hafize; YILMAZ, GÜLDEREN; BİNGÖL, ZEYNEBE; Kazaz, Cavit; Gülçin, İlhami; Güvenalp, Zühal

doi:10.1007/s11696-023-02900-6

Phytochemical content and enzyme inhibitory effect of Heptaptera triquetra (Vent.) Tutin fruit against acetylcholinesterase and carbonic anhydrase I and II isoenzymes

Yazarlar (8)

Ayşe Çiçek Kaya
Atatürk Üniversitesi, Türkiye

Prof. Dr. Hilal Özbek Atatürk Üniversitesi, Türkiye

Doç. Dr. Hafize Yuca Atatürk Üniversitesi, Türkiye

Doç. Dr. Gülderen YILMAZ Ankara Üniversitesi, Türkiye

Dr. Öğr. Üyesi Zeynebe BİNGÖL Tokat Gaziosmanpaşa Üniversitesi, Türkiye

Prof. Dr. Cavit Kazaz Atatürk Üniversitesi, Türkiye

Prof. Dr. İlhami Gülçin Atatürk Üniversitesi, Türkiye

Prof. Dr. Zühal Güvenalp Atatürk Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Chemical Papers (Q3)
Dergi ISSN	0366-6352 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	Türkçe	Basım Tarihi	06-2023
Cilt / Sayı / Sayfa	77 / 10 / 5829–5837	DOI	10.1007/s11696-023-02900-6
Makale Linki	http://dx.doi.org/10.1007/s11696-023-02900-6
UAK Araştırma Alanları	Farmakognozi

Özet

Abstract: Heptaptera triquetra (Vent.) Tutin (Apiaceae) is a potent plant with multiple effects. A recent study aimed to evaluate the bioactive profile of dichloromethane extract prepared from the H. triquetra fruit. For this purpose, isolation studies were performed, and the inhibitory activities of this extract against acetylcholinesterase (AChE) and human carbonic anhydrase isoenzyme (hCA) I and II were examined. According to the isolation studies, four sesquiterpene coumarins [umbelliprenin (1), colladin (3), colladonin (4), and samarcandin (5)] and one sterol [β-sitosterol (2)] were isolated. All the isolated compounds demonstrated effective enzyme inhibitory activities against AChE, hCA I, and hCA II when compared with the standards. Colladin (3) demonstrated the best activity with the IC50 values of 8.25 nM against AChE, 28.90 nM against hCA I, and 43.31 nM against hCA II. Samarcandin was first isolated from this plant. Standardized fruit extracts prepared from H. triquetra via its compounds could be potential phytotherapeutics for AD and glaucoma. Graphical abstract: [Figure not available: see fulltext.].

Anahtar Kelimeler

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Web of Science	5
Scopus	6

Phytochemical content and enzyme inhibitory effect of Heptaptera triquetra (Vent.) Tutin fruit against acetylcholinesterase and carbonic anhydrase I and II isoenzymes

Dergi Adı	CHEMICAL PAPERS
Yayıncı	Springer International Publishing AG
Açık Erişim	Hayır
ISSN	0366-6352
E-ISSN	2585-7290
CiteScore	4,3
SJR	0,431
SNIP	0,600

Phytochemical content and enzyme inhibitory effect of Heptaptera triquetra (Vent.) Tutin fruit against acetylcholinesterase and carbonic anhydrase I and II isoenzymes

Paylaş