Milrinone ameliorates ischaemia-reperfusion injury in experimental testicular torsion/detorsion rat model
Yazarlar (6)
Engin Kölükçü Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Doğan ATILĞAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Nihat ULUOCAK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Faik Alev Deresoy
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Muzaffer KATAR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Velid Ünsal Mardin Artuklu University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Andrologia | ||
| Dergi ISSN | 0303-4569 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 53 / 8 / 1–17 | DOI | 10.1111/and.14128 |
| Makale Linki | https://pubmed.ncbi.nlm.nih.gov/34091938/ | ||
| UAK Araştırma Alanları |
Üroloji
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| Özet |
| This experimental study aims to evaluate the efficacy of milrinone against ischaemia‐reperfusion injury due to testicular torsion/detorsion. Group 1 was defined as the control group. Testicular torsion/detorsion model was performed in Group 2. Group 3 had similar procedures to the rats in Group 2. In addition, 0.5 mg/kg of milrinone was administered intraperitoneally immediately after testicular torsion in Group 3. Histopathological examinations indicated a dramatic improvement in terms of inflammation, haemorrhage, oedema, congestion, Cosentino and Johnson scores in Group 3 compared to Group 2 (p = .037, p = .045, p = .018, p = .040, p = .033 and p = .03 respectively). Blood biochemical analyses, superoxide dismutase (SOD), glutathione peroxidase (GSH‐px) activity and total antioxidant status (TAS) levels increased significantly in Group 3 compared to Group 2 (p = .001, p = .024 and p < .001 … |
| Anahtar Kelimeler |
| ischaemia-reperfusion injury | milrinone | testicular torsion | treatment |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 26 |
| Scopus | 26 |
| Google Scholar | 30 |