Investigation of expression levels of MIR125A and MIR126 genes in chronic obstructive lung disease
Yazarlar (3)
Dr. Öğr. Üyesi Sümeyye Yıldırım Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Gökhan AYKUN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular Biology Reports (Q3) | ||
| Dergi ISSN | 0301-4851 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 53 / 1 / 1–0 | DOI | 10.1007/s11033-025-11143-5 |
| Makale Linki | https://doi.org/10.1007/s11033-025-11143-5 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| BackgroundChronic obstructive pulmonary disease (COPD) is a common lung disease characterized by airway inflammation, with high morbidity and mortality, and an increasing frequency with age. Small, non-coding RNA molecules known as microRNAs (miRNAs) control the expression of genes following transcription. In COPD, miR-125a-5p and miR-126-3p regulate disease progression; miR-125a-5p is usually low, linked to inflammation, while miR-126-3p varies. This study aims to examine their expression in COPD patients.MethodsThe expression levels of miR-125a-5p and miR-126-3p were measured using real-time polymerase chain reaction (RT-PCR) in a total of 52 healthy individuals and 53 patients diagnosed with COPD, including 16 with stable COPD and 37 experiencing acute exacerbations. Expression data of miRNAs were calculated by log2 − delta delta CT (2−ΔΔCt). Since most variables did … |
| Anahtar Kelimeler |
| Chronic obstructive pulmonary disease | MiR-125a-5p | MiR-126-3p |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |