MEFV gene pathogenic variants: a risk factor for dysmenorrhea in the Turkish population
Yazarlar (6)
Mehmet Can Nacar Adıyaman Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Ondokuz Mayıs Üniversitesi, Türkiye
Prof. Dr. Asker Zeki ÖZSOY Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fazlı DEMİRTÜRK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ayşe Feyda Nursal Hitit Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Nucleosides Nucleotides and Nucleic Acids (Q4) | ||
| Dergi ISSN | 1525-7770 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 03-2024 |
| Cilt / Sayı / Sayfa | 43 / 7 / 643–654 | DOI | 10.1080/15257770.2023.2293074 |
| Makale Linki | http://dx.doi.org/10.1080/15257770.2023.2293074 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| Background/AimThe Mediterranean fever (MEFV) gene codes for protein pyrin, which is among the modulators of inflammasome activity in innate immune cells. It was suggested that there is a relation between MEFV variations and inflammatory diseases. The aim of this study was to investigate MEFV gene variations in the patients with primary dysmenorrhea.MethodsThe prevalence of common MEFV gene variations (M694V, M680I, V726A, E148Q and R202Q) was investigated in 145 young women with primary dysmenorrhea and 135 unrelated healthy controls. MEFV gene variations were genotyped using PCR-based RFLP assay.ResultsNumber of childbirth and marriage were significantly lower in the study group than the controls, respectvely (p < 0.001, p = 0.001). Family history was statistically higher in the patient group (p < 0.001). In total, MEFV genotype and allele frequencies were significantly … |
| Anahtar Kelimeler |
| Mediterranean fever gene | variant |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |