Dual effect of methylene-tetrahydrofolate reductase and angiotensin-converting enzyme gene polymorphisms on the risk of acute ischemic stroke
Yazarlar (4)
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Ondokuz Mayıs Üniversitesi, Türkiye
Nurşah Başol Yalova Üniversitesi, Türkiye
Onur İncealtın
Istanbul Medeniyet University, Türkiye
Istanbul Medeniyet University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Genetics (Q4) | ||
| Dergi ISSN | 0022-1333 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2023 |
| Cilt / Sayı / Sayfa | 102 / 1 / 29–0 | DOI | 10.1007/s12041-023-01425-x |
| Makale Linki | http://dx.doi.org/10.1007/s12041-023-01425-x | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Ischemic stroke, a prevalent neurological disease, is the major reason of serious disability and death worldwide. Methylene-tetrahydrofolate reductase (MTHFR) gene polymorphisms increase homocysteine levels which also raise the risk of vascular diseases. Angiotensin-converting enzyme (ACE) gene polymorphisms can cause vascular reorganization and disrupt arterial wall stability. The aim of this study was to explore how the MTHFR and ACE gene polymorphisms are related to acute ischemic stroke. A total of 200 individuals (102 acute ischemic stroke patients and 98 healthy controls) were included in this case–control research. MTHFR gene C677T (rs1801133) and A1298C (rs1801131) polymorphisms were studied through polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) assays, ACE gene I/D polymorphism (rs1799752) was studied by PCR. The MTHFR C667T and … |
| Anahtar Kelimeler |
| ACE gene | ischemic stroke | MTHFR gene | neurological disease | stroke |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |