Methylene-tetrahydrofolate reductase gene C677T and A1298C polymorphisms as a risk factor for Crimean-Congo hemorrhagic fever
Yazarlar (4)
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Fazilet Duygu
Frankfurter Fachbereich Medizin, Türkiye
Frankfurter Fachbereich Medizin, Türkiye
Prof. Dr. Aydın Rüstemoğlu Aksaray Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Nucleosides Nucleotides and Nucleic Acids (Q4) | ||
| Dergi ISSN | 1525-7770 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 06-2022 |
| Cilt / Sayı / Sayfa | 41 / 9 / 878–890 | DOI | 10.1080/15257770.2022.2085296 |
| Makale Linki | http://dx.doi.org/10.1080/15257770.2022.2085296 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Crimean-Congo hemorrhagic fever (CCHF) is a deadly viral disease. Methylene-tetrahydrofolate reductase (MTHFR) has an important role in folate metabolism, and also in the formation of new cells, DNA synthesis, repair and methylation. We aimed to examine the relationship between MTHFR gene C677T (Ala222Val, rs1801133) and A1298C (Glu429Ala, rs1801131) polymorphisms with CCHF in a Turkish population. Totally 273 participants were included in the current study. One hundred forty-one participants were CCHF patients and one hundred thirty-two participants were healthy controls. The polymerase chain reaction (PCR) and further restriction fragment length polymorphism (RFLP) assays were applied to determine the genotypes of MTHFR polymorphisms. We did not find any differences between the CCHF patients and healthy controls in terms of allele and genotype distributions of both the C677T and … |
| Anahtar Kelimeler |
| A1298C | C677T | Crimean-Congo hemorrhagic fever | MTHFR | polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Scopus | 5 |
| Google Scholar | 8 |