eNOS and VEGF Variants Might Increase the Risk of Pancreatic Cancer
Yazarlar (6)
Hasan Dağmura
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Ondokuz Mayıs Üniversitesi, Türkiye
Prof. Dr. Özge Gümüşay Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ayşe Feyda Nursal Hitit Üniversitesi, Türkiye
Doç. Dr. Emin Daldal Samsun Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Cytology and Genetics (Q4) | ||
| Dergi ISSN | 0095-4527 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 55 / 2 / 177–182 | DOI | 10.3103/S0095452721020031 |
| Makale Linki | http://dx.doi.org/10.3103/s0095452721020031 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Background Endothelial nitric oxide synthase (eNOS) is essential in chronic inflammation and carcinogenesis. The association between variants in vascular endothelial growth factor (VEGF) and several cancers still remains uncertain. We studied whether there is a relation between eNOS/VEGF variants and risk of pancreatic cancer (PC). Materials and Methods This prospective case-control study included 76 PC patients (28 women and 48 men) and 100 healthy controls. Blood samples from all participants were genotyped for eNOS variable number tandem repeat (VNTR) and VEGF insertion/deletion (I/D) variants by PCR. Results There was a significant difference between groups for the eNOS intron 4 VNTR genotype distributions (p = 0.01). eNOS 4a/4b and 4b/4b genotypes were higher in patients with PC group compared to controls while eNOS 4a/4b genotype was more prevalent in control group than in … |
| Anahtar Kelimeler |
| eNOS | pancreatic cancer | variant | VEGF |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 4 |
| Google Scholar | 4 |