Impact of Endothelial NOS VNTR variant on suspectibility to diabetic neuropathy and type 2 diabetes mellitus
Yazarlar (10)
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ayse Feyda Nursal Hitit University, Türkiye
Suheyla Uzun Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Husniye Rustemoglu
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Payam Amiri Dashatan
Faculty Of Medicine, Türkiye
Faculty Of Medicine, Türkiye
Dr. Öğr. Üyesi Huseyin Soylu Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Aysegul Atmaca Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Aydin Rustemoglu Aksaray Üniversitesi, Türkiye
Arş. Gör. Nilufer Kuruca Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Current Neurovascular Research | ||
| Dergi ISSN | 1567-2026 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2020 |
| Cilt / Sayı / Sayfa | 17 / 5 / 700–705 | DOI | 10.2174/1567202617999201214230147 |
| Makale Linki | http://dx.doi.org/10.2174/1567202617999201214230147 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
|
||
| Özet |
| Purpose The aim of this study was to evaluate whether the VNTR intron 4b/4a variant in the eNOS gene is associated with type 2 diabetes mellitus (T2DM) and DPN. Methods A total of 598 subjects were enrolled in the study. eNOS VNTR 4b/4a variant was genotyped by polymerase chain reaction (PCR) method. Results eNOS VNTR intron 4b/4b genotype and b allele increased in patients with both DPN and T2DM compared healthy controls (p=0.0005, OR:1.94, p= 0.000002, OR:4.10, respectively). 4a/4b genotype was more prevalent in controls than in DPN and T2DM patients (p=0.00008, OR:0.46; p=0.000004, OR:0.24, respectively). eNOS VNTR b allele was more common in DPN patients and T2DM patients compared with controls (p=0.007, p=0.00002, respectively). Conclusion The eNOS VNTR “4b/4b” homozygous genotype and hence “4b”allele as a genetic risk factor for T2DM and DPN, which may … |
| Anahtar Kelimeler |
| Diabetes mellitus | Diabetic peripheral neuropathy | Endothelial NOS VNTR variant | Genotype | Hyperglycemia | Peripheral nerve |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Scopus | 5 |
| Google Scholar | 8 |