Influence of ESR1 Variants on Clinical Characteristics and Fibromyalgia Syndrome in Turkish Women
Yazarlar (5)
Habibe S. Arslan
Akdeniz University, Faculty Of Medicine, Türkiye
Akdeniz University, Faculty Of Medicine, Türkiye
Ayse F. Nursal
Hitit University, Türkiye
Hitit University, Türkiye
Ahmet Inanir Academic Pain-Hernia Center, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Endocrine Metabolic and Immune Disorders Drug Targets (Q3) | ||
| Dergi ISSN | 1871-5303 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2021 |
| Cilt / Sayı / Sayfa | 21 / 7 / 1326–1332 | DOI | 10.2174/1871530320666200910110915 |
| Makale Linki | http://dx.doi.org/10.2174/1871530320666200910110915 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Background Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain. It is more common in women than in men, and sex hormones may play a role in this predominance. Therefore, this research investigated the clinical findings among Turkish females and whether Estrogen-α (ESR1) gene variants are associated with FMS. Methods A total of 219 individuals were enrolled in this study. ESR1 variants (PvuII/XbaI) were genotyped using PCR-RFLP methods. The results of the analyses were evaluated for statistical significance. Results There was a significant association between the ESR1 PvuII and FMS risk among Turkish women. The ESR1 PvuII CC genotype and C allele were higher in the patients than those in the controls (p=0.021, p=0.007, respectively). A more statistically significant association was observed between the patients and the controls in terms of TT genotype vs … |
| Anahtar Kelimeler |
| Estrogen receptor-α | Fibromiyalgia syndrome | Pvull | Variant | Women | XbaI |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 4 |
| Google Scholar | 7 |