Effects of Paraoxonase-1 variants on course of severity and mortality of Crimean-Congo hemorrhagic fever
Yazarlar (6)
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Fazilet Duygu
University Of Health Sciences, Türkiye
University Of Health Sciences, Türkiye
Sener Barut
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Aydin Rustemoglu Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Nursah Basol Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Gene | ||
| Dergi ISSN | 0378-1119 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2019 |
| Cilt / Sayı / Sayfa | 687 / 1 / 188–192 | DOI | 10.1016/j.gene.2018.11.059 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0378111918312034 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Crimean-Congo hemorrhagic fever (CCHF) is an acute viral hemorrhagic fever caused by Crimean Congo hemorrhagic fever virus (CCHFV). Paraoxonase-1 (PON1) is a high density lipoprotein (HDL)-binding protein which defense the body against oxidative stress. To investigate the role of the PON1 gene in CCHF, we screened the genotypes of two single nucleotide polymorphisms (Q192R [rs662] and L55M [rs854560]) in CCHF patients stratified according to course of severity and mortality by using PCR-based RFLP assay. Overall, 132 patients diagnosed as CCHF were enrolled in this study. The frequencies of the three genotypes and two alleles of Q192R and L55M polymorphisms didn't show any statistically significant differences in terms of mortality and disease severity (p > 0.05). Any statistically significant differences were not found between severe and mild and fatal and non-fatal CCHF patients … |
| Anahtar Kelimeler |
| Crimean-Congo hemorrhagic fever | L55M | Paraoxonase-1 | Polymorphism | Q192R |
Science Direct
Effects of Paraoxonase-1 variants on course of severity and mortality of Crimean-Congo hemorrhagic fever
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 2 |