Significance of IL-1Ra and IL-6 gene variants in Turkish patients with Crimean-Congo hemorrhagic fever
Yazarlar (8)
Prof. Dr. Umut Safiye ŞAY COŞKUN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ayse Feyda Nursal Hitit University, Türkiye
Ferdi Gunes
Aydın Obstetrics And Pediatrics Hospital, Türkiye
Aydın Obstetrics And Pediatrics Hospital, Türkiye
Prof. Dr. Aydin Rustemoglu Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Abdullah Yayli Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Huseyin Sener Barut Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Asian Pacific Journal of Tropical Biomedicine | ||
| Dergi ISSN | 2221-1691 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 9 / 2 / 85–90 | DOI | 10.4103/2221-1691.250864 |
| Makale Linki | http://www.apjtb.org/text.asp?2019/9/2/85/250864 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Objective:To investigate the association between IL-1Ra variable number of tandem repeat (rs2234663), IL-6-597GA (rs1800797), IL-6-572GC (rs1800796) and the risk of Crimean-Congo hemorrhagic fever (CCHF) in the Turkish patients.Methods:This study included 50 patients infected with CCHF and 50 healthy controls. These variants were genotyped using polymerase chain reaction and/or restriction fragment length polymorphism method.Results:The distribution of the IL-6-572GC genotypes and alleles varied significantly between the patients and the controls. The subjects carrying IL-6-572GC GG genotype and G allele had increased risk of developing CCHF compared to the control group (P= 0.006, P= 0.014, respectively). IL-6-572GC GC genotype was higher in the controls than the patients (P= 0.006). For the triple genotype combinations, the 1/2-GC-GG genotype combination was detected more … |
| Anahtar Kelimeler |
| -572GC | -597GA | Crimean-Congo hemorrhagic fever | IL-1Ra | IL-6 | Variable number of tandem repeat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 3 |
| Google Scholar | 3 |