Effect of a functional variant of tumor necrosis factor-β gene in temporomandibular disorders: A pilot study
Yazarlar (6)
Kaan Yerliyurt Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ayse Feyda Nursal Hitit University, Türkiye
Akin Tekcan Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mehmet K. Tumer Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Clinical Laboratory Analysis (Q2) | ||
| Dergi ISSN | 0887-8013 Dergi Bilgileri (2019) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 33 / 1 / 22641–0 | DOI | 10.1002/jcla.22641 |
| Makale Linki | http://doi.wiley.com/10.1002/jcla.22641 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Background Temporomandibular disorders (TMD) are a group of conditions that cause chronic orofacial pain. The tumor necrosis factor β (TNF‐β) is a proinflammatory cytokine that is involved in the various aspects of the inflammatory process including organization and maintenance, and in the arrangement of cells at the inflammation site. The purpose of this study was to evaluate the correlation between TNF‐β +252A/G (rs909253) variant and susceptibility to TMD in a Turkish cohort. Methods The study included 104 patients (26 males, 78 females) with TMD and 126 healthy controls (44 males, 82 females). The TNF‐β +252A/G variant analysis was based on Polymerase Chain Reaction‐Restriction Fragment Length Polymorphism (PCR‐RFLP). Results There was no deviation from HWA for TNF‐β +252A/G variant in patient and control groups. There was significant difference in genotype and allele frequencies … |
| Anahtar Kelimeler |
| +252A/G | temporomandibular disorders | tumor necrosis factor β | variant |
