The evaluation of two genetic polymorphisms of paraoxonase 1 in patients with pulmonary embolism
Yazarlar (7)
Nurşah Başol Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Aslı Yasemen Savaş
Tokat State Hospital, Türkiye
Tokat State Hospital, Türkiye
Dr. Öğr. Üyesi Kayhan KARAKUŞ Cumhuriyet Üniversitesi, Türkiye
İlker Kaya
Tokat State Hospital, Türkiye
Tokat State Hospital, Türkiye
Prof. Dr. Serhat KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Clinical Laboratory Analysis | ||
| Dergi ISSN | 0887-8013 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2018 |
| Cilt / Sayı / Sayfa | 32 / 7 / 22455–0 | DOI | 10.1002/jcla.22455 |
| Makale Linki | http://doi.wiley.com/10.1002/jcla.22455 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Background and Objective Pulmonary embolism (PE) is caused by some genetic factors for more than half patients. Paraoxonase 1 (PON1) has significant anti‐oxidative and anti‐inflammatory effects. According to our knowledge, there is no study researching the relation between PON 1 gene polymorphisms and PE in the literature. Therefore, it is aimed to research possible impacts of PON 1 Q192R and L55M polymorphisms on PE, considering anti‐inflammatory and anti‐oxidative effects of PON 1 in Turkish population. Methods One hundred and five PE patients and one hundred and seventeen controls were enrolled in this study. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses for the PON1 gene Q192R and L55M polymorphisms. Results Any associations were not found between clinical and demographical … |
| Anahtar Kelimeler |
| L55M | polymorphism | PON1 | pulmonary embolism | Q192R |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 1 |
| Google Scholar | 4 |